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KMID : 1150720140030010034
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Integrative Medicine Research
2014 Volume.3 No. 1 p.34 ~ p.37
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Effect of hydroxypropyl methyl cellulose phthalate coating on digestive stability and intestinal transport of green tea catechins
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Chung Jae-Hwan
Lee Sang-Jun
Chung Jin-Oh
Oh Yu-Jin
Hwang Jeong-Ah
Kim Young-Kyung
Ko Sang-Hoon
Shim Soon-Mi
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Abstract
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Background: The purpose of this study was to investigate the effect of hydroxypropyl methyl cellulose phthalate (HPMCP) coating on the digestive stability and intestinal transport of green tea catechins (GTCs).
Methods: Two types of HPMCP coating were prepared: one type with size smaller than 500 μm (S-HPMCP) and the other with size larger than 500 μm (L-HPMCP). An in vitro gastrointestinal model system coupled with Caco-2 cells was used for estimating the bioavailability of GTCs. Ultraperformance liquid chromatography with a photodiode array detector was performed to analyze GTCs.
Results: The digestive stability of GTCs was enhanced up to 33.73% and 35.28% for S-HPMCP and L-HPMCP, respectively. Intestinal transport of the GTCs was increased to 22.98% and 23.23% for S-HPMCP and L-HPMCP, respectively. Overall, the bioavailability of GTCs increased by 4.08 and 11.71 times for S-HPMCP and L-HPMCP, respectively.
Conclusion: The results of this study confirm that coating with HPMCP could be a way to improve the digestive stability and intestinal transport of GTCs.
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KEYWORD
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digestive stability, green tea catechin, hydroxypropyl methyl cellulose phthalate, intestinal transport
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